v. 1. The beginnings of philosophy.--v. 2. The Eleatics and pluralists.

We investigate how the perceived uncertainty of a conditional affects a person's choice of conclusion. We use a novel procedure to introduce uncertainty by manipulating the conditional probability of the consequent given the antecedent. In Experiment 1, we show first that subjects reduce their choice of valid conclusions when a conditional is followed by an additional premise that makes the major premise uncertain. In this we replicate Byrne. These subjects choose, instead, a qualified conclusion expressing uncertainty. If subjects are (...) given a third statement that qualifies the likelihood of the additional premise, then the uncertainty of the conclusions they choose is systematically related to the suggested uncertainty. Experiment 2 confirms these observations in problems that omit the additional premise and qualify the first premise directly. Experiment 3 shows that the qualifying statement also affects the perceived probability of the consequent given the antecedent of the conditional. Experiment 4 investigates the effect of suggested uncertainty on the fallacies and shows that increases in uncertainty reduce the number of certain conclusions that are chosen while affirming the consequent but have no effect on denying the antecedent. We discuss our results in terms of rule theories and mental models and conclude that the latter give the most natural account of our results. (shrink)

It is often argued that human emotions, and the cognitions that accompany them, involve refinements of, and extensions to, more basic functionality shared with other species. Such refinements may rely on common or on distinct processes and representations. Multi-level theories of cognition and affect make distinctions between qualitatively different types of representations often dealing with bodily, affective and cognitive attributes of self-related meanings. This paper will adopt a particular multi-level perspective on mental architecture and show how a mechanism of subsystem (...) differentiation could have allowed an evolutionarily “old” role for emotion in the control of action to have altered into one more closely coupled to meaning systems. We conclude by outlining some illustrative consequences of our analysis that might usefully be addressed in research in comparative psychology, cognitive archaeology, and in laboratory research on memory for emotional material. (shrink)

Language employs various coordinators to connect propositions, a subset of which are “logical” in nature and thus analogous to the truth operators of formal logic. We here focus on two linguistic connectives and their negations: conjunction _and_ and (inclusive) disjunction _or_. Linguistic connectives exhibit a truth-conditional component as part of their meaning (their semantics), but their use in context can give rise to various implicatures and presuppositions (the domain of pragmatics) as well as to inferences that go beyond semantic/pragmatic properties (...) (the result of reasoning processes). We provide a comprehensive review of the role of the logical connectives in language and argue that three sets of factors—semantic, pragmatic, and those related to reasoning—are separate and separable, though some details may differ cross-linguistically. As a way to showcase the argument, we present two experiments in language comprehension in Spanish wherein pragmatic content was minimised and reasoning processes neutered, thus potentially highlighting what might be the default meanings of the connectives under study. In Experiment 1 we show that the conjunctive reading of inclusive disjunction is available in positive contexts other than in syntactically intricate cases such as downward entailing and free choice contexts, contrary to what has been claimed in the literature. In Experiment 2 we show that negated conjunctions and disjunctions in Spanish can easily receive the same interpretation when contrasted against the same context and, moreover, that these interpretations match those available in English, despite claims from the literature that linguistic connectives and local negation interact differently in English and Romance languages. (shrink)

Regulation of the cytoplasmic stability of mRNAs has recetly been identified as a major control mechanism which governs mRNA levels in a variety of eukaryotic systems. In this review we discuss what is known about several experimental systems that exhibit regulated mRNA stability, describe the mechanisms that cells may use to achieve control of mRNA degradation, and suggest areas of future investigation likely to provide new insights into this process.

Combining two thoughts into a compound mental representation is a central feature of our verbal and non-verbal logical abilities. We here approach this issue by focusing on the contingency that while natural languages have typically lexicalised only two of the possible 16 binary connectives from formal logic to express compound thoughts—namely, the coordinatorsandandor—some of the remainder appear to be entertainable in a non-verbal, conceptual representational system—alanguage of thought—and this suggests a theoretical split between the “lexicalisation” of the connectives and the (...) “learnability” of invented words corresponding to unlexicalised connectives. In avisual worldexperiment aimed at tracking comprehension-related as well as reasoning-related aspects of the capacity to represent compound thoughts, we found that participants are capable of learning and interpreting a made-up word standing for logic's NAND operator, a result that indicates that unlexicalised logical connectives are not only conceptually available, but can also be mapped onto new function words, as in the case of coordinators, or connectives, a class of words that do not usually admit new coinages. (shrink)

The diploblastic Cnidaria form one of the most ancient metazoan phyla and thus provide a useful outgroup for comparative studies of the molecular control of development in the more complex, and more often studied, triploblasts. Among cnidarians, the reef building coral Acropora is a particularly appropriate choice for study. Acropora belongs to the Anthozoa, which several lines of evidence now indicate is the basal class within the phylum Cnidaria, and has the practical advantages that its reproduction is predictable, external and (...) accessible and that the base content of its genome is not strongly biased. The Acropora system has already provided insights into ancestral linkages of homeobox genes and the evolution of the Pax genes, and has the potential to provide further new perspectives on the age, role in development, and evolution of these and other gene families. BioEssays 22:291–296, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Language’s intentional nature has been highlighted as a crucial feature distinguishing it from other communication systems. Specifically, language is often thought to depend on highly structured intentional action and mutual mindreading by a communicator and recipient. Whilst similar abilities in animals can shed light on the evolution of intentionality, they remain challenging to detect unambiguously. We revisit animal intentional communication and suggest that progress in identifying analogous capacities has been complicated by (i) the assumption that intentional (that is, voluntary) production (...) of communicative acts requires mental-state attribution, and (ii) variation in approaches investigating communication across sensory modalities. To move forward, we argue that a framework fusing research across modalities and species is required. We structure intentional communication into a series of requirements, each of which can be operationalised, investigated empirically, and must be met for purposive, intentionally communicative acts to be demonstrated. Our unified approach helps elucidate the distribution of animal intentional communication and subsequently serves to clarify what is meant by attributions of intentional communication in animals and humans. (shrink)

Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...) study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude and latency, and the end, but not the start, EP magnitude has a significant relationship to ongoing high gamma power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs. (shrink)

Recognition that biological systems are stabilized far from equilibrium by self-organizing, informed, autocatalytic cycles and structures that dissipate unusable energy and matter has led to recent attempts to reformulate evolutionary theory. We hold that such insights are consistent with the broad development of the Darwinian Tradition and with the concept of natural selection. Biological systems are selected that re not only more efficient than competitors but also enhance the integrity of the web of energetic relations in which they are embedded. (...) But the expansion of the informational phase space, upon which selection acts, is also guaranteed by the properties of open informational-energetic systems. This provides a directionality and irreversibility to evolutionary processes that are not reflected in current theory.For this thermodynamically-based program to progress, we believe that biological information should not be treated in isolation from energy flows, and that the ecological perspective must be given descriptive and explanatory primacy. Levels of the ecological hierarchy are relational parts of ecological systems in which there are stable, informed patterns of energy flow and entropic dissipation. Isomorphies between developmental patterns and ecological succession are revealing because they suggest that much of the encoded metabolic information in biological systems is internalized ecological information. The geneological hierarchy, to the extent that its information content reflects internalized ecological information, can therefore be redescribed as an ecological hierarchy. (shrink)

This paper argues that the Food and Drug Administration’s (FDA) policy for health and wellness apps is ethically problematic. Currently, the FDA does not regulate health and wellness apps that are not intended for medical use. As a result of this hands‐off policy, preventing harm to consumers is left primarily to developers and app marketplaces. We argue that the FDA’s duties to prevent harm and maintain accountability to the American public require that they play a much stronger role. We also (...) discuss concerns about efficiency and fostering innovation, and argue that while they should help shape FDA regulation of health and wellness apps, they do not justify complete absence of FDA involvement. -/- . (shrink)

This chapter contains sections titled: Introduction1 The Problem Arguments Against Materialism Type‐A Materialism Type‐B Materialism15 The Two‐Dimensional Argument Against Type‐B Materialism Type‐C Materialism Interlude Type‐D Dualism Type‐E Dualism Type‐F Monism Conclusions.

A collection of personal narratives and essays, Living Professionalism is designed to help medical students and residents understand and internalize various aspects of professionalism. These essays are meant for personal reflection and above all, for thoughtful discussion with mentors, with peers, with others throughout the health care provider community who care about acting professionally.

This paper is an edited transcription of a talk at the 1997 Montreal symposium on "Consciousness at the Frontiers of Neuroscience". There's not much here that isn't said elsewhere, e.g. in "Facing Up to the Problem of Consciousness" and "How Can We Construct a Science of Consciousness?"]].

Suicide has been condemned in our culture in one way or another since Augustine offered theological arguments against it in the sixth century. More recently, theological condemnation has given way to the view that suicidal behavior must always be symptomatic of emotional disturbance and mental illness. However, suicide has not always been viewed so negatively. In other times and cultures, it has been held that circumstances might befall a person in which suicide would be a perfectly rational course of action, (...) in the same sense that any other course of action could be rational: that it could be sensible, i.e., defensible by good reasons, or that it could be in keeping with the agent's fundamental interests. Indiscriminate use of modern life-sustaining technologies has renewed interest in the possibility of rational suicide. Today proponents of rational suicide tend to equate the rationality of suicide with the competence of the decision to commit suicide. (shrink)

Evolutionary psychologists sometimes suggest that "an evolutionary view of life can shed light on psyche" by revealing the "latent" psychology that underlies our "manifest" psychological image. At such moments, which become more frequent in popular works, explanations trade freely in subconscious motives whose goal is inclusive fitness. While some evolutionary psychologists explicitly deny that their aim is to uncover latent motivation, references to subconscious motives are nonetheless frequent in evolutionary psychology (and are even made by those explicitly denying postulation of (...) subconscious motives). These explanatory references to subconscious motives pose a dilemma. On the one hand, if they are literal, evolutionary psychology is vulnerable to a criticism frequently leveled against sociobiology: if subconscious motives toward inclusive fitness are the true determinants of human behavior, our behavior should more closely approximate full satisfaction of those motives (i.e. increased fitness) than it does. On the other hand, if references to subconscious motives are merely figurative -- like talk of "selfish" genes -- it must be explained how they are to be literally interpreted. Either way it is necessary to "deFreud" evolutionary psychology. I will thus provide an account of evolutionary psychological explanation, and how it functions, when purged of reference to subconscious motives. (shrink)

In this seminal work, acclaimed philosopher Bernhard Waldenfels deals with the problem of the nature of order after the “shattering of the world,” and the loss of the idea of a universal or fundamental order._ _ Order in the Twilight__ unites phenomenological methodology with recent work on the theory of order, normativity, and dialogue, as well as structuralism and Gestalt theory. Philosophically stringent, it expresses a more optimistic attitude than much modern philosophy, especially deconstruction._ Waldenfels passes the question of order (...) through numerous defining aspects, and concludes that there is not one global order, but rather various conflicting domains of order. Whenever the boundary of a vital or experiential domain is crossed, a discourse speaks at the boundary, not about it, and across a threshold without abolishing it. The rest is rationalization, i.e., an attempt to find a place in the respective order for what is to-be-ordered. But why, the author concludes, should a theory be more unambiguous than reality? _ Order in the Twilight__ is an important book at this time, because it may help lift the humanities out of the skeptical, relativistic disarray in which they have been embroiled in recent decades. Waldenfels does not attempt to dictate what reality should be; rather, he is open to any valid evidences. His book offers a solid footing to the human and social sciences as they seek to escape from deconstructive irrationalism. (shrink)

Activation of gene transcription in vivo is accompanied by an alteration of chromatin structure. The specific binding of transcriptional activators disrupts nucleosomal arrays, suggesting that the primary steps leading to transcriptional initiation involve interactions between activators and chromatin. The affinity of transcription factors for nucleosomal DNA is determined by the location of recognition sequences within nucleosomes, and by the cooperative interactions of multiple proteins targeting binding sites contained within the same nucleosomes. In addition, two distinct types of enzymatic complexes facilitate (...) binding of transcription factors to nucleosomal DNA. These include type A histone acetyltransferases (e.g. GCN5/ADA transcriptional adaptor complex) and ATP‐driven molecular machines that disrupt histone‐DNA interactions (e.g. SWI/SNF and NURF complexes). These observations raise the important question of what happens to the histones during chromatin remodeling. We discuss evidence supporting the retention of histones at transcription factorbound sequences as well as two alternative pathways of histone loss from gene control elements upon transcription factor binding: histone octamer sliding and histone dissociation. (shrink)

For over half a century there have been concerns about increases in the occurrence of academic misconduct by higher education students and this is now claimed to have reached crisis proportions (e.g. Mostrous & Kenber, 2016a ). This study explores the extent to which multi-national faculty judge the effectiveness of higher education institutions in dealing with such misconduct. A survey of multi-national higher education faculty was conducted to explore the perceived barriers to the implementation of academic integrity processes. It asked (...) faculty how likely some hypothetical scenarios of failures of such processes were to occur in the real world of higher education institutions. 63% of our participants perceived there to be institutional and/or faculty barriers to effectively dealing with academic misconduct. Mostly, they blamed the higher education model for this which, in the interests of mass education, has come to prioritise the need for institutions to focus more on their quantity of output as corporate business enterprises than on the integrity of their output as educators. In discussing participants’ comments, about the relationship of faculty to their employing institutions, Schein and Scheins’ ( 2016 ) theory of three levels of organisational culture was used. Participants’ comments suggested that, at the deepest level of organisational culture i.e. basic underlying taken-for-granted assumptions about beliefs and values, inadequate integrity measures have tended to become normalised. Despite the often considerable, efforts of the institutions, organisational barriers were noted which mitigate against faculty behaving professionally i.e. from doing a ‘good job’ in respect of student academic misconduct. Some blame was also placed on faculty. We argue that apparent institutional inability to effectively manage the integrity process, has potentially significant consequences for wider society. We discuss ways in which this situation might be improved including a recommendation that governments regulate this aspect of the corporate social responsibility of higher education institutions as they do other aspects, requiring that it be managed effectively. (shrink)

thought and problem solving in persons lacking natural language altogether would be a decisive challenge, but there is no clear evidence of any abstract thinking capabilities similar to those evinced by the scientists. Pinker cites languageless persons rebuilding broken locks - this is evidence of perhaps visual imagery, but not mentalese (at least not without quite a bit more detail and argument than we are given). Spiders, e.g., build marvelous things, but no inference to spiderese appears to be warranted. There (...) simply is much we don. (shrink)

Discussion of Fodor's doctrine of 'methodological solipsism' and Stich's principle of autonomy' has been concerned to show that these principles are incompatible with psychological theories which appeal to states with content (e.g. beliefs and desires). Concern with these issues, and the subsequent attempt to develop a notion of 'narrow' content which is solipsistic or autonomous, has, I believe, obscured a more fundamental issue: No theory which satisfies these principles would ever be able to explain behavior under descriptions which are in (...) fact important to psychology. But I do not simply argue that there are descriptions under which psychological theories will not in fact explain behavior; I argue that descriptions under which psychological theories do explain behavior are not compatible with solipsistic principles. I develop several thought experiments to demonstrate this. (shrink)

In this review, we discuss the application of mouse models to the identification and pre‐clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large‐scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross‐species comparative ‘omics‐based approaches to this problem. We highlight recent progress in modelling late‐stage disease using mice, (...) and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection. (shrink)

Those attempting to expound a comprehensive normative ethical theory are presumably motivated by the belief that there should be an ultimate reason people can give for their actions and a final response to the question of why we should act morally. Historically, one candidate for this ultimate end or reason is self-realization. To convince us of his theory the self-realizationist must successfully explicate the notion of the self—i.e., he must tell us what man’s distinctive nature or function is—and he must (...) have something to say about the perfecting of this self. (shrink)

The scope of Philosophy in Multiple Voices provides the reader with eight philosophical streams of thought-African-American, Afro-Caribbean, Asian-American, Feminist, Latin-American, Lesbian, Native-American and Queer-that introduce readers to alternative, complex philosophical questions concerning gendered, sexed, racial and ethnic identities, canon formation, and meta-philosophy. The overriding theme of the text is that philosophy is pluralistic in voice, rich in diversity, and ought to valorize democratic intellectual spaces of philosophical engagement.

Medical school curricula, although traditionally and historically dominated by science, have generally accepted, appreciated, and welcomed the inclusion of literature over the past several decades. Recent concerns about medical professional formation have led to discussions about the specific role and contribution of literature and stories. In this article, we demonstrate how professionalism and the study of literature can be brought into relationship through critical and interrogative interactions based in the literary skill of close reading. Literature in medicine can question the (...) meaning of “professionalism” itself, thereby resisting standardization in favor of diversity method and of outcome. Literature can also actively engage learners with questions about the human condition, providing a larger context within which to consider professional identity formation. Our fundamental contention is that, within a medical education framework, literature is highly suited to assist learners in questioning conventional thinking and assumptions about various dimensions of professionalism. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)